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  • SAB1400356 - Anti-ARHGEF10 antibody produced in mouse

SAB1400356 Sigma

Anti-ARHGEF10 antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-DKFZp686H0726, Anti-GEF10, Anti-MGC131664



Related Categories AR-AR, Alphabetical Index, Antibodies, Primary Antibodies
species reactivity   human
application(s)   capture ELISA: suitable
  indirect immunofluorescence: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ARHGEF10(9639)
biological source   mouse
conjugate   unconjugated



ARHGEF10 (AAH40474.1, 1 a.a. ~ 380 a.a) full-length human protein.


General description

The gene ARHGEF10 (Rho guanine nucleotide exchange factor 10) is mapped to human chromosome 8p23. It belongs to the Rho-specific guanine nucleotide exchange factor family. The protein contains tandem Dbl homology (DH) domain, pleckstrin homology (PH) domain and putative transmembrane domains.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Biochem/physiol Actions

ARHGEF10 (Rho guanine nucleotide exchange factor 10) works as a guanine nucleotide exchange factor for RhoA, RhoB and RhoC. It is involved in atherosclerotic cerebral infarction and mutation in ARHGEF10 is associated with increased risk of atherothrombotic stroke. Mutation in ARFGEF10 is also linked with slowed nerve conduction velocities and thin myelination of peripheral nerves.

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Safety Information

RIDADR  NONH for all modes of transport
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