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SAB1400512 Sigma

Anti-ATAD2 antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-DKFZp667N1320, Anti-MGC29843, Anti-MGC5254, Anti-PRO2000

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Properties

Related Categories AS-ATG, Alphabetical Index, Antibodies, Antibodies to Most Studied Epigenetic Genes, Epigenetics,
species reactivity   human
application(s)   capture ELISA: suitable
  indirect immunofluorescence: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ATAD2(29028)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

ATAD2 (AAH19909.1, 1 a.a. ~ 362 a.a) full-length human protein.

Sequence
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKMEQEVENFSCSR

General description

ATAD2 (ATPase family, AAA domain containing 2) is an evolutionarily conserved AAA+ nuclear protein consisting of a bromodomain and a double AAA+ class ATPase domain. It is localized in in the nucleus with a molecular mass of ~170kDa. Its expression has been observed in different types of cancerous cells such as human breast cancer. It is mapped to chromosome 8q24.13.

Physical form

Solution in phosphate buffered saline, pH 7.4

Application

Anti-ATAD2 antibody produced in mouse is suitable for capture ELISA, indirect immunofluorescence, and western blot.

Features and Benefits

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Biochem/physiol Actions

ATAD2 (ATPase family, AAA domain containing 2) is associated with various cellular processes such as DNA replication, chromatin remodeling, transcription, and DNA damage. In the E2-Induced cell Proliferation and cell cycle progression, ATAD2 functions as an ERα (estrogen receptor) coactivator and facilitates E2-stimulated expression of cell cycle regulators by protein complex-remodeling phenomena. It also plays a vital role in the tumorigenesis. ATAD2 alters chromatin accessibility at MYC target loci by directly interacting with MYC as a cofactor. The chromatin accessibility further modifies transcriptional expression of the MYC gene.

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Safety Information

RIDADR  NONH for all modes of transport
Protocols & Articles

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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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