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SAB1400726 Sigma

Monoclonal Anti-SETDB2 antibody produced in mouse

clone 1E2, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-C13orf4, Anti-CLLD8, Anti-CLLL8, Anti-DKFZp586I0123, Anti-DKFZp761J1217

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Properties

Related Categories Alphabetical Index, Antibodies, Primary Antibodies, SE-SF
species reactivity   human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   1E2, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2aκ
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... SETDB2(83852)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

SETDB2 (NP_114121.1, 620 a.a. ~ 719 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL

General description

Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM

Physical form

Solution in phosphate buffered saline, pH 7.4

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RIDADR  NONH for all modes of transport
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