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SAB2500063 Sigma

Anti-α2-AntiPLASMIN antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-A2AP, Anti-SERPINF2

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Properties

Related Categories Alphabetical Index, Antibodies, PJ-PN, Primary Antibodies
species reactivity   human
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... SERPINF2(5345)
biological source   goat
conjugate   unconjugated

Description

Immunogen

Peptide with sequence C-KDFLQSLKGFPRGDK from the internal region of the protein sequence according to NP_000925.2.

General description

α-2 antiplasmin (AAP) is a member of the Serpin superfamily. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. The gene encoding this protein is localized on human chromosome 17.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Biochem/physiol Actions

α-2 antiplasmin (AAP) is the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. α-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.

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Safety Information

Symbol  GHS07  GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P305 + P351 + P338
RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
15

References

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