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  • SAB2500067 - Anti-Amphiphysin/AMPH antibody produced in goat

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SAB2500067 Sigma

Anti-Amphiphysin/AMPH antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-AMPH1, Anti-HGNC:471

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Properties

Related Categories AM-AN, Alphabetical Index, Antibodies, Primary Antibodies
species reactivity   rat, mouse, canine, human
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... AMPH(273)
biological source   goat
conjugate   unconjugated

Description

Immunogen

Peptide with sequence C-KRKDESRISKAE from the internal region of the protein sequence according to NP_001626.1; NP_647477.1.

General description

AMPH (Amphiphysin) is a 128kD peripheral protein highly distributed in nervous system including many neurons, certain endocrine cell types, and spermatocytes. It exists as two isoforms having different molecular weights 128 and 108kD respectively, in breast cancer. In human, it is located on chromosome 7, region p13-p14. It is a member of amphiphysin family and consists of an SH3 domain.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Application

Anti-Amphiphysin/AMPH antibody produced in goat is suitable for western blot.

Biochem/physiol Actions

AMPH (Amphiphysin) is involved in several pleotropic functions including endocytosis, actin function, and cell growth control. It plays an important role in synaptic vesicle endocytosis of axon terminals. Alteration in AMPH gene is associated with heritable disorders of the nervous system, endocrine tissues and male fertility. It also has correlation with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. It is also involved in the neoplastic growth cone dynamics.

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Safety Information

Symbol  GHS07  GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P305 + P351 + P338
RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
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References

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