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SAB2501392 Sigma

Anti-EPS8 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Epidermal growth factor receptor pathway substrate 8

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Properties

Related Categories Alphabetical Index, Antibodies, EO-ER, Primary Antibodies
species reactivity   human, rat, mouse, canine
application(s)   immunohistochemistry: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EPS8(2059)
biological source   goat
conjugate   unconjugated

Description

Immunogen

Peptide with sequence SGVESFDEGSSH, from the C-terminal region of the protein sequence according to NP_004438.3

General description

The gene EPS8 (epidermal growth factor receptor pathway substrate 8) is mapped to human chromosome 12p12. The protein has a phosphotyrosine-binding (PTB) domain at the N-terminal, an SH3 (src homology 3) domain and an effector domain at the C-terminal.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

EPS8 (epidermal growth factor receptor pathway substrate 8) is a substrate for tyrosine kinases, such as epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and ERBB2 (erb-b2 receptor tyrosine kinase 2). In addition, it also interacts with the Src non-receptor tyrosine kinase. The protein is involved in Rac signaling and receptor endocytosis. It also regulates dendritic cell migration, morphogenesis of intestinal cells and microvilli, and stereocilia activity. It is upregulated in pancreatic cancer and oral squamous cell carcinoma. Mutation in EPS8 is associated with autosomal recessive profound deafness.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
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References

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