Monoclonal Anti-β-Catenin antibody produced in mouse
clone 2H3, purified immunoglobulin, buffered aqueous glycerol solution
DOWNLOAD MSDS (PDF)Synonym: Anti-CTNNB, Anti-DKFZp686D02253, Anti-FLJ25606, Anti-FLJ37923
Properties
| Related Categories | 2F-2M, AA - CA, Alphabetical Index, Antibodies, Antibodies against Adhesion, Attachment, and Matrix Factors, |
| species reactivity | human |
| application(s) | western blot: suitable |
| clone | 2H3, monoclonal |
| antibody form | purified immunoglobulin |
| form | buffered aqueous glycerol solution |
| isotype | IgG2a |
| mol wt | antigen mol wt 85.3 kDa |
| shipped in | dry ice |
| storage temp. | −20°C |
| Gene Information | human ... CTNNB1(1499) |
| NCBI accession no. |
NM_001904
|
Description
Immunogen
Recombinant protein expressed in E. coli corresponding to amino acids 531-781 of human β-catenin
Antigen Background
β-Catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the contact inhibition signal, which instructs cells to stop dividing once an epithelial sheet is complete.
Physical form
Solution in phosphate buffered saline containing 1% bovine serum albumin, 50% glycerol, and 0.02% sodium azide.
Price and Availability
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