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SAB3500062 Sigma

Anti-Seasonal H1N1 Hemagglutinin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Common flu H1, Anti-Flu H1, Anti-HA, Anti-Seasonal Influenza A (H1N1) Hemagglutinin

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, HF-HI, Primary Antibodies,
biological source   rabbit
antibody form   affinity isolated antibody
clone   polyclonal
form   buffered aqueous solution
species reactivity   viral
application(s)   indirect ELISA: suitable
conjugate   unconjugated
NCBI accession no.   ACA28844
UniProt accession no.   B0VX44
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin (4). The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups (5). This antibody is specific for the seasonal H1N1 influenza Hemagglutinin and will not recognize the corresponding Hemagglutinin sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).

Immunogen

Hemagglutinin antibody was raised against a synthetic peptide from the Hemagglutinin protein. The peptide sequence is unique from the peptide sequence for product SAB3500058 and SAB3500060. This antibody is a cognate pair with product number SAB3500063.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500062.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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SBP3500062 Seasonal H1N1 Hemagglutinin Blocking Peptide for SAB3500062

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