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  • SAB3500066 - Anti-Swine H1N1 Neuraminidase antibody produced in rabbit

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SAB3500066 Sigma

Anti-Swine H1N1 Neuraminidase antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-S-OIV A NA, Anti-S-OIV A Neuraminidase, Anti-Swine flu N1, Anti-Swine-Origin Influenza A (H1N1) Neuraminidase

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, HF-HI, Primary Antibodies,
biological source   rabbit
antibody form   affinity isolated antibody
clone   polyclonal
form   buffered aqueous solution
species reactivity   viral
application(s)   indirect ELISA: suitable
conjugate   unconjugated
NCBI accession no.   ACQ76308
UniProt accession no.   C4AL28
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin (4). The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups (5). This antibody is specific for the novel swine influenza Neuraminidase and will not recognize the corresponding Neuraminidase sequence from the seasonal H1N1 influenza (A/Georgia/20/2006 (H1N1)).

Immunogen

Neuraminidase antibody was raised against a synthetic peptide from the novel swine influenza Neuraminidase protein. This antibody is a cognate pair with product SAB3500065.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500066.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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RIDADR 
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SBP3500066 Swine H1N1 Hemagglutinin Blocking Peptide for SAB3500066

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