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SAB3500067 Sigma

Anti-HAAO antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-3-HAO, Anti-4-Dioxygenase, Anti-3-Hydroxyanthranilate oxygenase, Anti-3-hydroxyanthranilate 3, Anti-HAD, Anti-HAO

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, H1-HE,
species reactivity   human, mouse, rat
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... HAAO(23498)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_036337
UniProt accession no.   P46952

Description

Immunogen

HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.

Antigen Background

HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500067.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500067 HAAO Blocking Peptide for SAB3500067

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