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SAB3500068 Sigma

Anti-EPHA10 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-EPH receptor A10, Anti-Ephrin type-A receptor 10, Anti-FLJ16103

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, C-E, EO-ER,
species reactivity   human, rat, mouse
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EPHA10(284656)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_001092909
UniProt accession no.   Q5JZY3

Description

Immunogen

EphA10 antibody was raised against a 14 amino acid peptide of near the amino terminus of human EphA10.

Antigen Background

Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell–cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500068.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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SBP3500068 EphA10 Blocking Peptide for SAB3500068

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