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SAB3500069 Sigma

Anti-SYPL2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Synaptophysin-like protein 2, Anti-MG29, Anti-Mitsugumin 29

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, Primary Antibodies, R-S,
species reactivity   human, mouse, rat
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... SYPL2(284612)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_001035799
UniProt accession no.   Q5VXT5

Description

Immunogen

SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.

Antigen Background

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500069.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
15

References

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SBP3500069 SYPL2 Blocking Peptide for SAB3500069

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