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SAB3500073 Sigma

Anti-ARL15 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ADP-ribosylation factor-like 15, Anti-ADP-ribosylation factor-related protein 2, Anti-ARFRP2

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Properties

Related Categories A-B, AR-AR, Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides,
species reactivity   mouse, human, rat
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ARL15(54622)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_061960
UniProt accession no.   Q9NXU5

Description

Immunogen

ARL15 antibody was raised against a 17 amino acid peptide near the center of human ARL15.

Antigen Background

ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of cholera toxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL15 (ADP-ribosylation factor-like 15), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. Other members of this protein family include ARL11, thought to be a tumor suppressor and may play a role in the regulation of apoptosis, ARL2 which plays an important role in microtubule dynamics and cell cycle progression, and ARL4, which may play a role in neurogenesis during embryonic development. The gene encoding ARL15 maps to chromosome 5p15 in humans. At least three isoforms of ARL15 are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500073.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500073 ARL15 Blocking Peptide for SAB3500073

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