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  • SAB3500075 - Anti-CIP75 antibody produced in rabbit

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SAB3500075 Sigma

Anti-CIP75 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Connexin-43-interatcting protein 75, Anti-A1U, Anti-Ataxin-1 ubiquitin-like-interacting protein, Anti-UBIN, Anti-UBQLN4, Anti-Ubiquilin-4

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, C-E, CI-CN,
species reactivity   human, rat, mouse
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... UBQLN4(56893)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   Q9NRR5
UniProt accession no.   Q9NRR5

Description

Immunogen

CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.

Antigen Background

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500075.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500075 CIP75 Blocking Peptide for SAB3500075

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