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SAB3500076 Sigma

Anti-MPYS antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ERIS, Anti-MITA, Anti-STING, Anti-TMEM173, Anti-Transmembrane protein 173

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, K-M, MO-MR,
species reactivity   human, mouse
application(s)   immunocytochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   predicted mol wt 31-42 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TMEM173(340061)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_938023
UniProt accession no.   Q86WV6

Description

Immunogen

MPYS antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.

Antigen Background

MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500076.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500076 MPYS Blocking Peptide for SAB3500076

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