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SAB3500077 Sigma

Anti-MAK10 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab1

Synonym: Anti-EGAP, Anti-Embryonic growth-associated protein homolog, Anti-amino-acid N-acetyltransferase subunit

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, K-M, M1-MAR,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MAK10(60560)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_078911
UniProt accession no.   Q5VZE5

Description

Immunogen

MAK10 antibody was raised against a 19 amino acid peptide near the amino terminus of human MAK10.

Antigen Background

The MAK10 gene encodes a 733-amino acid protein with several regions of similarity to T cell receptor alpha-subunit V (variable) regions in yeast. The mammalian homologue of yeast MAK10, also known as EGAP, is one subunit of a novel N-terminal acetyltransferase (NAT) that is highly conserved among vertebrate species. It is expressed in a variety of tissues in the developing rat embryo but restricted in expression in the adult, remaining detectable only in tissues undergoing continual cell renewal or in cells responding to pathological injury. The MAK10-NAT complex is an essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development. This complex functionally co-assembles in mammalian cells to regulate cell proliferation and is essential for embryonic development, at least in part through the regulation of target of rapamycin (TOR) signaling events. At least two isoforms of MAK10 are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500077.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500077 MAK10 (AB1) Blocking Peptide for SAB3500077

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