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SAB3500079 Sigma

Anti-PALB2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-FANCN, Anti-Partner and localizer of BRCA2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, N-P, P-PA,
species reactivity   rat, mouse, human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PALB2(79728)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   Q86YC2
UniProt accession no.   Q86YC2

Description

Immunogen

PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.

Antigen Background

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500079.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500079 PALB2 Blocking Peptide for SAB3500079

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