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SAB3500083 Sigma

Anti-IRGC antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Immunity-related GTPase cinema 1, Anti-Interferon-inducible GTPase 5, Anti-CINEMA, Anti-Ligp5

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, IQ-IZ,
species reactivity   mouse, human, rat
application(s)   immunocytochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... IRGC(56269)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_062558

Description

Immunogen

IRGC antibody was raised against a 13 amino acid peptide near the amino terminus of human IRGC.

Antigen Background

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will only recognize the IRGCa isoform.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500083.

Price and Availability


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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500083 IRGC Blocking Peptide for SAB3500083

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