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SAB3500087 Sigma

Anti-ABIN3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Listeria-induced gene protein, Anti-A20-binding inhibitor of NF-kappaB activation 3, Anti-LIND, Anti-TNFAIP3 interacting protein 3, Anti-TNIP3

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Properties

Related Categories A-B, A1-AB, Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides,
species reactivity   mouse, human
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNIP3(79931)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_079149
UniProt accession no.   Q96KP6

Description

Immunogen

ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.

Antigen Background

The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500087.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500087 ABIN3 Blocking Peptide for SAB3500087

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