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  • SAB3500090 - Anti-Seasonal H1N1 Nonstructural Protein 1 antibody produced in rabbit

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SAB3500090 Sigma

Anti-Seasonal H1N1 Nonstructural Protein 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-NS1, Anti-influenza NS1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, HF-HI, Primary Antibodies,
biological source   rabbit
antibody form   affinity isolated antibody
clone   polyclonal
form   buffered aqueous solution
species reactivity   viral
application(s)   indirect ELISA: suitable
conjugate   unconjugated
NCBI accession no.   ABP49398
UniProt accession no.   A4U724
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR. This antibody is specific for the seasonal H1N1 influenza NS1 and will not recognize the corresponding NS1 sequence from the Swine-Origin H1N1 influenza (A/California/04/2009 (H1N1)).

Immunogen

NS1 antibody was raised against a synthetic peptide from the Seasonal Influenza NS1 protein.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500090.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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RIDADR 
NONH for all modes of transport
WGK Germany 
2
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SBP3500090 Seasonal H1N1 Nonstructural Protein 1 Blocking Peptide for SAB3500090

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