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  • SAB3500092 - Anti-Seasonal H1N1 Nucleocapsid Protein antibody produced in rabbit

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SAB3500092 Sigma

Anti-Seasonal H1N1 Nucleocapsid Protein antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Common flu NP, Anti-NP

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, HF-HI, Primary Antibodies,
biological source   rabbit
antibody form   affinity isolated antibody
clone   polyclonal
form   buffered aqueous solution
species reactivity   viral
application(s)   indirect ELISA: suitable
conjugate   unconjugated
NCBI accession no.   ACX46223
UniProt accession no.   I3QSJ8
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. The influenza A virus polymerase transcribes and replicates eight virion RNA (vRNA) segments, among which the nucleocapsid protein (NP), thought to control whether mRNA or cRNA is produced. The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. It was recently found several NP mutations that affected the efficient incorporation of multiple viral-RNA (vRNA) segments into progeny virions even though a single vRNA segment was incorporated efficiently. This indicates that the respective conserved amino acids in NP may be critical for the assembly and/or incorporation of sets of eight vRNA segments. This antibody is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).

Immunogen

NP antibody was raised against a synthetic peptide from the Seasonal H1N1 NP protein.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500092.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
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SBP3500092 Seasonal H1N1 Nonstructural Protein Blocking Peptide for SAB3500092

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