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  • SAB3500093 - Anti-JMJD1A antibody produced in rabbit

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SAB3500093 Sigma

Anti-JMJD1A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-JHDM2A, Anti-JHMD2A, Anti-KDM3A, Anti-Lysine-specific demethylase 3A, Anti-TSGA

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, J,
species reactivity   human, mouse, rat
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   predicted mol wt 145 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KDM3A(55818)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_060903
UniProt accession no.   Q9Y4C1

Description

Immunogen

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Antigen Background

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500093.

Price and Availability


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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500093 JMJD1A Blocking Peptide for SAB3500093

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