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  • SAB3500094 - Anti-JMJD1C antibody produced in rabbit

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SAB3500094 Sigma

Anti-JMJD1C antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Jumonji domain containing 1C protein, Anti-TRIP8

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, J,
species reactivity   mouse, human, rat
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... JMJD1C(221037)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_116165
UniProt accession no.   Q15652

Description

Immunogen

JMJD1C antibody was raised against a 20 amino acid peptide from near the amino terminus of human JMJD1C.

Antigen Background

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist. This antibody will not cross-react with JMJD1A or JMJD1B.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500094.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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SBP3500094 JMJD1C Blocking Peptide for SAB3500094

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