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SAB3500095 Sigma

Anti-JMJD2A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Jumonji domain-containing protein 2A, Anti-KDM4A, Anti-Lysine-specific demethylase 4A

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies to Histones, Antibodies to Transcription Factors, Antibodies with Corresponding Blocking Peptides,
species reactivity   rat, mouse, human
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KDM4A(9682)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   CAH71021
UniProt accession no.   O75164

Description

Immunogen

JMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.

Antigen Background

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500095.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500095 JMJD2A Blocking Peptide for SAB3500095

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