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SAB3500096 Sigma

Anti-JMJD2B antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Jumonji domain-containing protein 2B, Anti-KDM4B, Anti-Lysine-specific demethylase 4B

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, J,
species reactivity   human, mouse, rat
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KDM4B(23030)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   AAI36612

Description

Immunogen

JMJD2B antibody was raised against a 16 amino acid peptide from near the center of human JMJD2B.

Antigen Background

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500096.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500096 JMJD2B Blocking Peptide for SAB3500096

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