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SAB3500098 Sigma

Anti-AGTR2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-AT2, Anti-AT2R, Anti-Angiotensin II receptor type 2, Anti-MRX88

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Properties

Related Categories A-B, AE-AK, Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   predicted mol wt 40 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... AGTR2(186)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   AAS45437
UniProt accession no.   P50052

Description

Immunogen

AGTR2 antibody was raised against a 16 amino acid peptide from near the center of human AGTR2.

Antigen Background

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500098.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
15

References

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SBP3500098 AGTR2 Blocking Peptide for SAB3500098

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