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SAB3500099 Sigma

Anti-PROSAPIP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Proline-rich synapse-associated protein-interacting protein 1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, N-P, PR-PR,
species reactivity   rat, human, mouse
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ProSAPiP1(9762)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_055546
UniProt accession no.   O60299

Description

Immunogen

Prosapip1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip1.

Antigen Background

Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3’s PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins’. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500099.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500099 Prosapip1 Blocking Peptide for SAB3500099

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