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  • SAB3500100 - Anti-PROSAPIP2 antibody produced in rabbit

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SAB3500100 Sigma

Anti-PROSAPIP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-SINTBAD, Anti-TANK-binding kinase 1-binding protein, Anti-TBK1-binding protein 1, Anti-TBKBP1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, N-P, PR-PR,
species reactivity   mouse, human, rat
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TBKBP1(9755)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_055541
UniProt accession no.   A7MCY6

Description

Immunogen

Prosapip2 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip2.

Antigen Background

Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappaB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500100.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500100 Prosapip2 Blocking Peptide for SAB3500100

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