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SAB3500104 Sigma

Anti-RWDD3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab1

Synonym: Anti-RSUME, Anti-RWD domain containing 3, Anti-RWD-containing sumoylation enhancer

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, Primary Antibodies, R-S,
species reactivity   mouse, rat, human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... RWDD3(25950)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_056300
UniProt accession no.   Q9Y3V2

Description

Immunogen

RWDD3 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human RWDD3.

Antigen Background

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500104.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500104 RWDD3 (AB1) Blocking Peptide for SAB3500104

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