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SAB3500108 Sigma

Anti-CENPO antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CENP-O, Anti-Centromere protein O, Anti-Interphase centromere complex protein 36

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, C-E, CE-CH,
species reactivity   human, rat, mouse
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CENPO(79172)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_077298
UniProt accession no.   Q9BU64

Description

Immunogen

CENPO antibody was raised against a 16 amino acid peptide from near the center of human CENPO.

Antigen Background

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500108.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500108 CENPO Blocking Peptide for SAB3500108

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