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SAB3500109 Sigma

Anti-CKIP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Casein kinase-2-interacting protein 1, Anti-Family O member 1, Anti-Leckstrin homology domain containing, Anti-PLECKHO1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, C-E, CI-CN,
species reactivity   mouse, human, rat
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PLEKHO1(51177)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_057358
UniProt accession no.   Q53GL0

Description

Immunogen

CKIP1 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human CKIP1.

Antigen Background

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha’, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500109.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500109 CKIP1 Blocking Peptide for SAB3500109

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