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SAB3500110 Sigma

Anti-GAS antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Glutamate-rich coactivator interacting with SRC1, Anti-PA1, Anti-PTIP-associated 1 protein

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, G-GC,
species reactivity   mouse, human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... C16orf53(79447)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_078792
UniProt accession no.   Q9BTK6

Description

Immunogen

GAS antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human GAS.

Antigen Background

Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERa), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERa is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500110.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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SBP3500110 GAS Blocking Peptide for SAB3500110

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