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  • SAB3500112 - Anti-MIMITIN antibody produced in rabbit

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SAB3500112 Sigma

Anti-MIMITIN antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Assembly factor 2, Anti-MMTN, Anti-NADH dehydroxygenase (ubiquinone) 1 alpha subcomplex, Anti-NDUFA12L, Anti-NDUFAF2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, K-M, MF-MN,
species reactivity   human
application(s)   immunofluorescence: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... NDUFAF2(91942)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_777549
UniProt accession no.   Q8N183

Description

Immunogen

Mimitin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Mimitin.

Antigen Background

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500112.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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SBP3500112 Mimitin Blocking Peptide for SAB3500112

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