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  • SAB3500113 - Anti-FRMPD1 antibody produced in rabbit

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SAB3500113 Sigma

Anti-FRMPD1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-FERM and PDZ domain-containing 1, Anti-FRMD2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, FP-FZ,
species reactivity   human
application(s)   immunofluorescence: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FRMPD1(22844)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_055722
UniProt accession no.   Q5SYB0

Description

Immunogen

FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.

Antigen Background

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500113.

Price and Availability


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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500113 FRMPD1 Blocking Peptide for SAB3500113

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