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  • SAB3500114 - Anti-FRMPD2 antibody produced in rabbit

SAB3500114 Sigma

Anti-FRMPD2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-FERM and PDZ domain-containing 2, Anti-PDZD5C, Anti-PDZK5C



Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, F-J, FP-FZ,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FRMPD2(143162)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   NP_001018081
UniProt accession no.   Q68DX3



FRMPD2 antibody was raised against a 15 amino acid peptide from near the amino terminus of human FRMPD2.

Antigen Background

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.


The action of this antibody can be blocked using blocking peptide SBP3500114.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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SBP3500114 FRMPD2 Blocking Peptide for SAB3500114

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