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SAB3500123 Sigma

Monoclonal Anti-PD-1 antibody produced in mouse

clone 12A7D7, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-CD279, Anti-PDCD-1, Anti-Programmed cell death 1

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Properties

Related Categories Alphabetical Index, Antibodies, PD-PG, Primary Antibodies
species reactivity   mouse, rat, human
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
clone   12A7D7, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PDCD1(5133)
biological source   mouse
conjugate   unconjugated
UniProt accession no.   Q15116

Description

Immunogen

raised against an ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Antigen Background

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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