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SAB3500127 Sigma

Monoclonal Anti-ORAI1 antibody produced in mouse

clone 6D11A11, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-Calcium release-activated calcium channel protein 1, Anti-TMEM142A, Anti-Transmembrane protein 142A

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Properties

Related Categories Alphabetical Index, Antibodies, O, Primary Antibodies
biological source   mouse
antibody form   purified immunoglobulin
clone   6D11A11, monoclonal
form   buffered aqueous solution
mol wt   predicted mol wt 33 kDa
species reactivity   rat, mouse, human
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
conjugate   unconjugated
UniProt accession no.   Q96D31
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Immunogen

raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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References

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