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  • SAB3500128 - Monoclonal Anti-IRAKL antibody produced in mouse

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SAB3500128 Sigma

Monoclonal Anti-IRAKL antibody produced in mouse

clone 1F12C1, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-IL-1-Receptor Associated Kinase

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Properties

Related Categories Alphabetical Index, Antibodies, IQ-IZ, Primary Antibodies
biological source   mouse
antibody form   purified immunoglobulin
clone   1F12C1, monoclonal
form   buffered aqueous solution
species reactivity   human, mouse
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
conjugate   unconjugated
UniProt accession no.   P51617
shipped in   dry ice
storage temp.   −20°C

Description

Antigen Background

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

Immunogen

raised against a recombinant protein corresponding to amino acids 618 - 712 of human IRAK.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
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