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SAB3500468 Sigma

Monoclonal Anti-EndoG antibody produced in mouse

clone 7G1C10, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-Endonuclease G

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Properties

Related Categories Alphabetical Index, Antibodies, EJ-EN, Primary Antibodies
species reactivity   mouse, rat, human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   7G1C10, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ENDOG(2021)
biological source   mouse
conjugate   unconjugated
NCBI accession no.   Q14249
UniProt accession no.   Q14249

Description

Immunogen

Mouse monoclonal EndoG antibody was raised against a recombinant protein corresponding to amino acids 51 – 140 of human EndoG.

General description

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

Physical form

Supplied in PBS with 0.02% sodium azide.

Application

Monoclonal Anti-EndoG antibody produced in mouse is suitable for indirect ELISA and western blot.

Biochem/physiol Actions

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked to cardiac hypertrophy and Parkinson′s disease.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
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References

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