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  • SAB4503480 - Anti-GGH, C-Terminal antibody produced in rabbit

SAB4503480 Sigma

Anti-GGH, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym: γ-Glu-X carboxypeptidase, γ-glutamyl hydrolase, Conjugase, GH



Related Categories Alphabetical Index, Antibodies, GD-GL, Primary Antibodies
species reactivity   human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 35 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... GGH(8836)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   Q92820



Synthesized peptide derived from human GGH

General description

Anti-GGH Antibody detects endogenous levels of total GGH protein.
The gene GGH (γ-glutamyl hydrolase) is mapped to human chromosome 8q12.1. The protein is mainly present in the lysosomes.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Biochem/physiol Actions

GGH (γ-glutamyl hydrolase) is involved in the removal of γ-linked polyglutamates, thereby hydrolysing (anti)folylpoly-γ-glutamates. The enzyme controls the intracellular folate pools and folate metabolism. During the treatment of acute lymphoblastic leukemia (ALL), mutation in the GGH gene is linked with efficacy and side effects of methotrexate (MTX). It is responsible for changing a long-chain methotrexate polyglutamates (MTX-PGs) into a short-chain MTX-PGs and finally to MTX. Mutation in this gene at -401C>T enhances the response of cisplatin-based chemoradiotherapy in cervical carcinoma. The levels of GGH are higher in invasive breast cancer tumors and are associated with the development and progression of the cancer.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
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