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  • SAB4503570 - Anti-DGKI, C-Terminal antibody produced in rabbit

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SAB4503570 Sigma

Anti-DGKI, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym: DAG kinase ι, DGK-ι, DGKI, diacylglycerol kinase

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Properties

Related Categories Alphabetical Index, Antibodies, DE-DL, Primary Antibodies
species reactivity   human, rat
application(s)   indirect immunofluorescence: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 116 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... DGKI(9162)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   O75912

Description

Immunogen

Synthesized peptide derived from human DGKI

General description

Anti-DGKI Antibody detects endogenous levels of total DGKI protein.

DGKI (Diacylglycerol kinase iota) is a small, integral membrane protein belonging to the type IV diacylglycerol kinase subfamily. It is mapped on chromosome 7q32.3-q33. The members of the DGK family consist of a catalytic domain and at least two cysteine-rich regions. In type IV family members, it has four ankyrin repeats and a carboxy terminal PDZ binding domain.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application

Anti-DGKI, C-Terminal antibody produced in rabbit is suitable for indirect immunofluorescence and western blot.

Biochem/physiol Actions

DGKI (Diacylglycerol kinase iota) is mainly involved in the maintenance of intracellular concentration of diacylglycerol by phosphorylating other lipids in addition to DAG. DGKI has been predicted to be a potential gene for tumor suppression in colorectal cancers and mutation in DGKI has been linked to the melanoma.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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References

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