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SAB4503626 Sigma

Anti-EFTUD2 antibody produced in rabbit

affinity isolated antibody

Synonym: 116 kDa U5 small nuclear ribonucleoprotein component, 116 kDa, KIAA0031, SNRP116, U5 snRNP- specific protein

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Properties

Related Categories Alphabetical Index, Antibodies, E-EI, Primary Antibodies
species reactivity   human, mouse
application(s)   immunohistochemistry: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 109 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... EFTUD2(9343)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   Q15029

Description

Immunogen

Synthesized peptide derived from human EFTUD2

General description

Anti-EFTUD2 Antibody detects endogenous levels of total EFTUD2 protein.

EFTUD2 (Elongation factor Tu GTP binding domain containing 2) is a member of the U5 small nuclear ribonucleoprotein particle (snRNP) located on chromosome region 17q21.31. It encodes a small GTPase (116kDa) component of the major spliceosome. It consists of a GTP-binding domain and several other conserved domains homologous to the translational elongation factor EF-2. Its N-terminal domain has an acidic domain.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application

Anti-EFTUD2 antibody produced in rabbit is suitable for immunohistochemistry and western blot.

Biochem/physiol Actions

EFTUD2 (Elongation factor Tu GTP binding domain containing 2) acts as a component of the spliceosome complex during translocation of mRNA on the ribosome. It produces mature mRNAs by binding to GTP during the processing of precursor mRNAs. Haploinsufficient genetic mutation in EFTUD2 causes a sporadic malformation syndrome, mandibulofacial dysostosis with microcephaly (MFDM), characterized with severe craniofacial abnormalities, microcephaly, growth delay, hearing loss, cleft palate, choanal atresia and dysmorphic features.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Peer-Reviewed Papers
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