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SAB4503682 Sigma

Anti-ARHGEF10 antibody produced in rabbit

affinity isolated antibody

Synonym: ARHGEF10, Rho guanine nucleotide exchange factor 10

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Properties

Related Categories AR-AR, Alphabetical Index, Antibodies, Primary Antibodies
species reactivity   human
application(s)   immunohistochemistry: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 151 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... ARHGEF10(9639)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   O15013

Description

Immunogen

Synthesized peptide derived from human ARHGEF10

General description

Anti-ARHGEF10 Antibody detects endogenous levels of total ARHGEF10 protein.
The gene ARHGEF10 (Rho guanine nucleotide exchange factor 10) is mapped to human chromosome 8p23. It belongs to the Rho-specific guanine nucleotide exchange factor family. The protein contains tandem Dbl homology (DH) domain, pleckstrin homology (PH) domain and putative transmembrane domains.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Biochem/physiol Actions

ARHGEF10 (Rho guanine nucleotide exchange factor 10) works as a guanine nucleotide exchange factor for RhoA, RhoB and RhoC. It is involved in atherosclerotic cerebral infarction and mutation in ARHGEF10 is associated with increased risk of atherothrombotic stroke. Mutation in ARFGEF10 is also linked with slowed nerve conduction velocities and thin myelination of peripheral nerves.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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