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  • SAB4503717 - Anti-MED24, C-Terminal antibody produced in rabbit

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SAB4503717 Sigma

Anti-MED24, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym: Mediator complex subunit 24, Mediator of RNA polymerase II transcription subunit 24, Thyroid hormone receptor-associated protein 4, Trap100, hTRAP100

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Properties

Related Categories Alphabetical Index, Antibodies, MB-ME, Primary Antibodies
species reactivity   rat, mouse, human
application(s)   indirect immunofluorescence: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 110 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MED24(9862)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   O75448

Description

Immunogen

Synthesized peptide derived from human MED24

General description

Mediator complex subunit 24 (MED24), also known as thyroid hormone receptor associated protein 100 (TRAP100), is encoded by the gene mapped to human chromosome 17q21.1. The protein is ubiquitously expressed in human tissues, but at high level in skeletal muscle, heart, and placenta. TRAP100 is characterized with a notional zinc finger at N-terminal, a putative ATP/GTP binding site in the central region, and six dispersed LXXLL motifs.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application

Anti-MED24, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Mediator complex subunit 24 (MED24)/ thyroid hormone receptor associated protein 100 (TRAP100), which is a subunit of TRAP coactivator complex, might promote TRAP-mediated enhancement of nuclear receptor - signaling pathways. The MED1/MED24 complex plays an essential role in the pubertal mammary gland development and growth of breast carcinoma cells via the rat sarcoma (RAS)-mitogen-activated protein kinase (MAPK) pathway. The MED1/MED24 complex is over-expressed in female breast cancer (FBC). In Drosophila, mutation of gene encoding MED24 inhibit salivary gland cell death, caspase activation, and the breakdown of nuclear lamins.

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RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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