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  • SAB4504077 - Anti-phospho-Arachidonate 5 Lipoxygenase (pSer271) antibody produced in rabbit

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SAB4504077 Sigma

Anti-phospho-Arachidonate 5 Lipoxygenase (pSer271) antibody produced in rabbit

affinity isolated antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Phosphoproteins at Phosphoserine (pSer),
species reactivity   mouse, human, rat
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 77 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... ALOX5(240)
biological source   rabbit
conjugate   unconjugated
NCBI accession no.   P09917

Description

Immunogen

The antiserum was produced against synthesized peptide derived from human Arachidonate 5 Lipoxygenase around the phosphorylation site of Ser271.

General description

The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘C2-like’ domain at the amino terminal that is involved in Ca2+-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Biochem/physiol Actions

The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds such as 5(S)-hydroxyeicosatetraenoic acid (5-HETE), leukotriene B4 (LTB4), and other leukotrienes. These leukotrienes and lipoxins function as mediators of inflammatory response. ALOX5 has been implicated in tumorigenesis and may serve as a potential therapeutic target and biomarker.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Peer-Reviewed Papers
15

References

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