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  • SAB4504246 - Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit

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SAB4504246 Sigma

Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit

affinity isolated antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Phosphoproteins at Phosphothreonine (pThr),
species reactivity   human
application(s)   ELISA: suitable
  western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   mol wt 76 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IRAK1(3654)
biological source   rabbit
conjugate   unconjugated
Featured Industry   Research Pathology
NCBI accession no.   P51617

Description

Immunogen

The antiserum was produced against synthesized peptide derived from human IRAK1 around the phosphorylation site of Thr209.

General description

Interleukin 1 receptor associated kinase 1 (IRAK1) is a serine/threonine kinase encoded by the gene with 14 exons mapped to human chromosome xq28. The encoded protein belongs to the IRAK family. IRAK1is characterized with a death domain at its N-terminal end which is involved in protein interaction.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application

Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit has been used in immunoprecipitation assay.

Biochem/physiol Actions

Interleukin 1 receptor associated kinase 1 (IRAK1) is a vital element of the interleukin-1 receptor (IL-1R) signaling pathway. IRAK1 functions as a downstream effector molecule of the toll like receptor (TLR) signaling pathway, implicated in inflammation, autoimmunity and cancer. IRAK1 is associated with systemic lupus erythematosus (SLE) and it is overexpressed in various cancer types including lung cancer. IRAK1, is considered to be a potential therapeutic target in myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), triple-negative breast cancer (TNBC) metastasis and paclitaxel resistance. Increased expression of IRAK1 leads to head and neck squamous cell carcinomas (HNSCCs). Therefore, inhibition of IRAK1 might be a new therapeutic strategy in HNSCC.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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