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SAB5300484 Sigma

Monoclonal Anti-EIF4EBP1 antibody produced in mouse

clone 9E12D9, ascites fluid

Synonym: 4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I

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Properties

Related Categories Alphabetical Index, Antibodies, E-EI, Primary Antibodies
species reactivity   human
application(s)   direct ELISA: 1:10,000
  western blot: 1:500-1:2,000
clone   9E12D9, monoclonal
antibody form   ascites fluid
isotype   IgG1
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... 4E-BP1(1978)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

Purified recombinant fragment of 4EBP1 expressed in E.coli.

General description

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is mapped to human chromosome 8p12.

Antigen Background

Mouse monoclonal antibody raised against 4E-BP1

Physical form

Ascitic fluid containing 0.03% sodium azide.

Features and Benefits

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Biochem/physiol Actions

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) encodes a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E). eIF4E is a multisubunit complex that recruits 40S ribosomal subunits to the 5’ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of eIF4Ebp1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA.The encoded protein participates in cell proliferation, apoptosis, invasion, and metastasis. It functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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