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SAB5300510 Sigma

Monoclonal Anti-BIRC5 antibody produced in mouse

clone 2H5H2, ascites fluid

Synonym: API4, BIRC5, EPR-1

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Properties

Related Categories Alphabetical Index, Antibodies, B-BI, Primary Antibodies
species reactivity   human
application(s)   direct ELISA: 1:10,000
  western blot: 1:500-1:2,000
clone   2H5H2, monoclonal
antibody form   ascites fluid
isotype   IgG1
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... Survivin(332)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

Purified recombinant fragment of Survivin expressed in E.coli.

General description

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5 ), also known as Survivin, is a transmembrane glycoprotein receptor encoded by the BIRC5 gene in humans. It consists of a unique cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich (26%) cytoplasmic tail with at least 15 potential phosphorylation sites.

Antigen Background

Mouse monoclonal antibody raised against Survivin

Physical form

Ascitic fluid containing 0.03% sodium azide.

Application

Monoclonal Anti-BIRC5 antibody produced in mouse is suitable for direct ELISA (1:10,000), flow cytometry (1:200-1:400), immunohistochemistry (1:200-1:1,000), indirect immunofluorescence (1:200-1:1,000) and western blot (1:500-1:2,000).

Features and Benefits

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Biochem/physiol Actions

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5) functions as a cell surface receptor for factor Xa. It is predicted to be a potential factor in protease-dependent cellular effector functions.It also behaves as a receptor for factor Xa during the cell surface assembly of proteolytic activities and leukocyte mitogenesis. A study reports that the expression of BIRC5 can be controlled by mRNA splicing. It is an inhibitor of apoptosis and is expressed in various malignancies.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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