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SIRNA Sigma

MISSION® siRNA Product Offerings

Custom and Predesigned siRNA

Synonym: Custom siRNA, High-throughput siRNA, siRNA gene sets, siRNA library, siRNA panels, siRNA pools, siRNA

 Visit the Functional Genomics learning center to read and learn more about our entire gene knockdown, knockout and expression portfolio
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Predesigned siRNA

Extensive collection of human, mouse and rat siRNA. Multiple sequences are available for every gene, with rankings to indicate performance.


  • Scale: 10, 25, 50, and 250 nmol
  • Purification: Desalt or HPLC
  • Sequence Length: 21 bases
  • Modifications: Not available for this item
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

Custom siRNA

Custom siRNA sequences with a wide range of modifications, purifications and quantities to tailor your unique sequence.


  • Scale: 10, 25, 50, and 250 nmol
  • Purification: Desalt or HPLC
  • Sequence Lengths: 19 - 27 bases
  • Modifications: Comprehensive offering of modifications and dyes (2'-O-Methyl, Amine, Cyanine dyes, Fluorescein, 6-FAM, Biotin, Phosphate, Thiol, Abasic, Phosphorothioate linkages, 2'-Fluoro).
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • For additional purifications, sequence length or modifications,
    email customorders@sial.com
  • Custom siRNA sequence design available for a variety of species,
    Learn more

Fast siRNA

Expedite your siRNA order! Orders are prioritized in the production process with a turn-around-time of only 3 days.


  • FAST siRNA is delivered in solution at concentrations of 50µM (2 OD) or 100µM (5 OD).
  • US orders must be received by 11 AM CST. European orders must be received by 11 AM CET.
  • Easy to use Fast siRNA ordering tool.

siRNA Pools

siRNA pools are available for pre-designed or custom siRNA sequences. Each pool provides 4 duplexes at 5 nmol per duplex (20 nmol total/pool). Each siRNA duplex is also provided at 5 nmol in individual tubes.


  • Scale: 2 OD /10 nmol per duplex
  • Purification: Desalt or HPLC
  • Sequence Length: 21 bases
  • Modifications: Comprehensive offering of modifications and dyes (2'-O-Methyl, Amine, Cyanine dyes, Fluorescein, 6-FAM, Biotin, Phosphate, Thiol, Abasic, Phosphorothioate linkages, 2'-Fluoro).
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

iScale Oligos™ - siRNA

siRNA provided in larger quantities for in vivo, high throughput or diagnostic projects.


  • Amount: 1 – 10 mgs, 50 mgs – 1 G
  • Purification: Desalt, RPC (cartridge purified), HPLC and In vivo quality
  • Sequence Length: 19 - 45 bases
  • Comprehensive offering of modifications including dyes, amines, biotin, linkers, etc.
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • In vivo option includes HPLC-purification to >/= 90%, desalt, filtration and endotoxin testing.
  • To inquire for availability of additional quantities, modifications or purifications, email acctreps-hou@sial.com

siRNA Libraries and Panels

Human and Rat Druggable Libraries and Mouse Kinase Panels.


  • Choose from 17 human or rat panels including kinase, phosphatase and GPCR. Click browse for a list of additional panels.
  • 3 individual siRNA provided per gene with quantities to allow for multiple screenings and hit follow-up.
  • Amount: 0.25, 0.5 or 1 nmol depending on the panel/library; supplied in 96 well plates
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry
plates

  • 96 Well, 8-Channel

siRNA Controls

Universal Negative Controls.


  • Two distinct siRNA control sequences designed for use in Human, Mouse, or Rat cells.
  • Validated with Agilent 40K human gene arrays to ensure no significant nonspecific gene interactions.
  • Functionally validated to show no immune response via qRT PCR.
  • Learn more

Positive Control siRNA.


  • Validated human and rat positive controls to simplify transfection optimization.
  • Learn more

siRNA Nano scale

Small scale siRNA screening option for human kinase or phosphatase genes. Available as individuals or a gene family set.


  • Scale: 0.25 nmol
  • Purification: Desalt
  • Sequence Length: 21 bases
  • Modification: Not available for this item.
  • Quality Control: Individual strands are analyzed by mass spectrometry. Duplex formation is verified by a non-denaturing PAGE gel. siRNA quantity is systematically validated by UV absorbance at 260 nm.
  • Format: Supplied dry

RNA Oligos

  • Scale: 0.05, 0.2, 1.0 µmole
  • Purification: Desalt, HPLC and PAGE
  • Sequence Length: 7 - 45 bases
  • Modification options available
  • Quality Control: 100% Mass Spectrometry
  • Format: Supplied dry
  • Learn more about RNA Oligos

MISSION® siRNA Transfection Reagent

  • Superior gene silencing in a wide variety of eukaryotic cell types
  • For use with siRNA, esiRNA, miRNA mimics and Synthetic miRNA inhibitors
  • Learn more

N-TER™ Nanoparticle siRNA Transfection System

  • Peptide transfection reagent for use in difficult to transfect cells.
  • Learn more

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?