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SML0025 Sigma

Safinamide mesylate salt

≥98% (HPLC)

Synonym: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

  • CAS Number 202825-46-5

  • Empirical Formula (Hill Notation) C17H19FN2O2 · xCH4O3S

  • Molecular Weight 302.34 (free base basis)

  •  MDL number MFCD15145475

  •  PubChem Substance ID 329825096

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
InChI Key   YKOCHIUQOBQIAC-YDALLXLXSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
color   white to tan
solubility   H2O: ≥15 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

Safinamide mesylate salt may be used in cell signaling studies.

Biochem/physiol Actions

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

Features and Benefits

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Articles

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The voltage-gated calcium channels constitute one group of a superfamily of ion channels that also includes sodium and potassium channels and amongst which exists functional, sequence and topological...
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Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Dopamine and Norepinephrine Metabolism

While reuptake of catecholamines plays an important role in regulating their synaptic levels, metabolism also contributes significantly to the termination of catecholamine neurotransmission. The rela...
Keywords: Atomic layer deposition, Clinical, Dopamine agents, Metabolism, Metabolites, Neurotransmission, Parkinson Disease

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials. A variety of toxins and chemicals are known to either block or m...
Keywords: Analgesics, Atomic absorption spectroscopy, Central Nervous System, Gene expression, Insecticides, Neurotoxins

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